Fig. 1. The scheme depicts coagulation pathways in the solid lines (—) and fibrinolysis pathways in the dashed lines (– – –). Anticoagulant steps are drawn in dash-dotted lines (-·-·-). Roman numerals indicate coagulation factors. Prethrombotic markers of a hypercoagulable state are depicted in boxes. a2-AP = 2-antiplasmin, AT III = antithrombin III, DD = fibrin D-dimer, F1+2 = prothrombin fragments 1+2, FDP = fibrinogen/fibrin degradation products, FPA = fibrinopeptide A, PAP = plasmin-2-antiplasmin complex, t-PA = tissue plasminogen activator, PAI-1 = type 1 plasminogen activator inhibitor, and vWF = von Willebrand factor. The sign "" indicates inhibition steps of thrombin, plasmin, and t-PA. See text for description and explanation of circled numbers.