Figure 1. Path analysis of daughters’ immune and hormone functions, effects of mothers’ disease on daughters’ life (frequency of meetings and caregiving burden), mothers’ and daughters’ psychologic distress, and mothers’ stage of disease. The model was assessed by means of four serial multiple regressions. The last stage tested the full model, in which daughters’ NCA, IL-2 secretion, or IL-12 secretion were regressed on the foregoing variables. Numbers on arrows are standard regression coefficients; * p <.05. ** p <.01. Mothers’ variables. Daughters’ variables. GSI = Global Severity Index; NCA = natural cytotoxic activity; NE = norepinephrine.