Figure 2. Panel of median cortisol during 2-day diurnal baseline at waking, wake + 30 minutes, 12:00 PM, 5:00 PM, and 9:00 PM and mean cortisol response during baseline and Trier Social Stress Test (TSST) for women with metastatic breast cancer (MBC) (middle figure). Depressed women were significantly lower on wake + 30-minute cortisol levels. We have also included the mean cortisol response during baseline and TSST for depressed and nondepressed women who either have MBC or who were at risk for cardiovascular disease (50) to illustrate the relative hyporesponsiveness of the patients with MBC.