Figure 3. Plasma hormone levels (mean ± standard error) in drug vehicle- (V) or chemotherapy- (C) treated mice at 0, 1, and 5 days after drug vehicle or chemotherapy injection. Significance symbols: treatment (•), group (*), and day (). (A) Corticosterone (CORT): CORT levels were significantly higher at 1 day for C-II than for V-II mice (p < .05; •). (B) Growth hormone (GH): before vehicle/chemotherapy injection (0 days), GH levels did not differ significantly among mice in the housing conditions. At 1 day after drug vehicle injection, GH levels were higher in GI mice compared with all other housing conditions (p values <.05; *). Also, GH levels in GI mice were significantly higher at 1 and 5 days than at 0 days (p values <.05; ). Overall, GH levels were significantly higher in V-GI mice than in C-GI mice (p < .01; •). (C) Testosterone (T): for V mice, significant increases in T levels were seen at 5 days in GG mice compared with IG and GI mice (p values <.05; *). Also for GG mice, T levels were significantly higher at 5 days than those at 1 day (p < .01; ). No significant differences in T levels were seen in C mice or between V and C mice.