Figure 2. Mean aerobic capacity and exercise tolerance after 16 weeks of treatment, adjusting for pretreatment levels of outcome variable, age, gender, race, and past major depressive disorder. Participants in the exercise conditions showed greater aerobic capacity (left panel) and exercise tolerance (right panel) compared with patients in the medication or placebo conditions. Error bars represent 95% confidence limits. Planned contrasts for aerobic capacity were as follows: all exercise versus placebo, p = .0001; medication versus placebo, p = .420; all exercise versus medication, p = .0001. For exercise tolerance, the contrast results were: all exercise versus placebo, p = .0001; medication versus placebo, p = .410; all exercise versus medication, p = .0001. VO2 = oxygen consumption; Sup = supervised exercise; Med = medication; Plac = placebo.