Figure 1. Theoretical model of biobehavioral influences on HIV-1 disease progression. Psychosocial factors = stress, depression, coping, social support, temperament, and other CNS-mediated influences on neural and endocrine activity, (A) CNS-mediated effects of psychosocial factors on neural/endocrine activity, (B) neural/endocrine influences on HIV-1 replication, (C) effects of HIV-1 replication on clinical disease progression.