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Psychosomatic Medicine 12:86-88 (1950)
© 1950 American Psychosomatic Society

Adrenocortical Response to Physiologic Stress in Schizophrenia

J. H. FRIEDLANDER M.D.1, R. PERRAULT M.D.1, W. J. TURNER M.D.1, and S. P. GOTTFRIED Ph.D.1

1 Medical Research Unit, Veterans Administration Hospital Northport, New York

The levels of adrenocortical secretion as manifested by 17-ketosteroid determinations were ascertained on admission and at a varying period during hospitalization in a group of schizophrenics. The results were correlated with the patients' clinical condition.

The pituitary adrenocortical response to physiologic stress (epinephrine and insulin) was studied. This was accomplished by determining the changes caused by stress in serum ascorbic acid, urinary acid, lymphocyte counts, urinary and plasma corticosteroids, and protein fractionation. The results were equivocal with the exception of the urinary corticosteroids. This indicates either that these tests are not accurate indices of adrenal function or that the stress given was not of sufficient intensity. A third possibility, that the schizophrenic will give varying results with the above procedures, dependent upon the severity of his illness, may be discounted since the controls were likewise unpredictable.




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