Psychosomatic Medicine 14:306-308 (1952)
© 1952 American Psychosomatic Society

Psychological Reactions to Cortisone

A Clinical Note

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In the case reported, cortisone produced a mild euphoria or elation. This seemingly was due to a more or less specific pharmacological action of the drug rather than to suggestion, the relief of a symptom, or to an improved general condition.

At the same time that the patient experienced the elation, she also felt very apprehensive. The latter feeling resulted from her temptation to become dependent upon a drug effect which would take the place of her usual adjustment patterns. Since the pharmacogenic elation was not a part of herself but rather something external, it could be withdrawn at any time. If she were left without this "borrowed" feeling and without her old defenses, she might become deeply depressed and suicidal.

Thus it is apparent that the reaction to cortisone in this instance was determined by a pharmacological action of the drug and by the personality make-up of the patient.

It is possible that since cortisone produces a feeling of elation (and in some instances a relief of pain), addiction may be a serious problem in emotionally predisposed people.

Cortisone, also, should afford us an opportunity to study affective responses which are intensified by a pharmacological agent.