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Psychosomatic Medicine 16:489-495 (1954)
© 1954 American Psychosomatic Society

Glutathione Metabolism in Men under Psychological Stress

HAROLD PERSKY Ph.D.1

1 Institute for Psychosomatic and Psychiatric Research and Training, Michael Reese Hospital Chicago, Illinois

Blood reduced glutathione concentration is significantly diminished 5 to 10 hours after such psychological stresses as jumping from a 34-foot tower while in harness, parachute jumping, and participation in night-infiltration exercises, but not after extremely severe, purely physical activity. The exact nature of the psychological stress capable of evoking this metabolic response is unknown. It is postulated that severe psychological stress operating over long periods may produce irreversible depression of the blood glutathione level and its associated metabolic dysfunctions.

Submitted on September 10, 1953






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Copyright © 1954 by the American Psychosomatic Society