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Psychosomatic Medicine 24:337-342 (1962)
© 1962 American Psychosomatic Society

Salivation Rate: A Physiologic Correlate of Improvement in Hospitalized Depressed Patients Treated with Three Antidepressant Medications

BERNARD L. BUSFIELD JR. M.D.1 and HENRY WECHSLER Ph.D.1

1 Massachusetts Mental Health Center and Department of Psychiatry, Harvard Medical School, Boston, Mass.

Severely depressed hospitalized patients who improve on antidepressant medication have significantly higher pretreatment salivation rates than those who do not improve (p = .005).

Analysis of the variables of age, sex, diagnosis, and initial severity of depression shows that none decisively alters the relationship of salivation rate and improvement.

Pretreatment salivation rate correlates with treatment outcome most strongly for patients on Marplan and somewhat for patients on Tofranil. This suggests that salivation rates may predict treatment outcome only for those patients treated with MAO inhibitors.

Subjective perception of dry mouth does not correlate with treatment outcome.

Submitted on June 23, 1961






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Copyright © 1962 by the American Psychosomatic Society