Psychosomatic Medicine 25:69-77 (1963)
© 1963 American Psychosomatic Society

Effect on Anxiety of Increasing the Plasma Hydrocortisone Level

¹ Institute of Psychiatric Research, Indiana University Medical Center Indianapolis, Indiana
² United States Public Health Service Research Trainee in Psychiatry.
³ Present address: Department of Endocriniology and Human Reproduction, Albert Einstein Medical Center, Philadelphia 41, Pa.

Hydrocortisone and a placebo were administered on separate occasions to a group of 32 normal men in a 2 x 2, double-blind, cross-over design. The hydrocortisone did not increase the mean Affect Adjective Check List scores but did raise the Institute for Personality and Ability Testing's Anxiety Scale scores and Sum C of the Rorschach test. These findings were taken to indicate that anxiety-proneness rather than current anxiety were elevated by the administration of the hormone.

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