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Psychosomatic Medicine 27:27-30 (1965)
© 1965 American Psychosomatic Society

Parameters Relevant to the Experimental Production of "Stress" in the Mouse

STANFORD B. FRIEDMAN M.D.1 and ROBERT ADER Ph.D.1

1 Department of Pediatrics and the Department of Psychiatry, University of Rochester Medical Center, Rochester, N. Y

The interactions between an unconditioned noxious stimulus (electric shock) and a conditioned stimulus (light) were systematically investigated in mice, utilizing change in body weight as a quantitative manifestation of "stress." Merely moving mice from standard laboratory cages to experimental cages resulted in a significant decrease in weight gain. Mice subjected to periodic shock preceded by a stimulus light lost a greater amount of weight during the observation period than mice subjected to any of the other experimental conditions.

Submitted on April 30, 1964






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Copyright © 1965 by the American Psychosomatic Society