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Psychosomatic Medicine 27:399-407 (1965)
© 1965 American Psychosomatic Society

Brain Norepinephrine and Behavior

A Behavioral and Kinetic Study

JAMES W. MAAS M.D.1 and D. HAROLD LANDIS B.S.1

1 Section on Psychosomatic Medicine, Adult Psychiatry Branch, Clinical Investigations, National Institute of Mental Health, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.

The behavioral effects induced by the injection of l-norepinephrine into the cisterna magna of dogs have been examined. As an aid to understanding the behavioral shifts observed, the over-all fate of dl-norepinephine-H3 injected via this route was followed through time, and kinetic models were constructed which adequately describe the level of the isotope in cerebrospinal fluid and blood. These models suggest that approximately 71% of dl-norepinephrine-H3 injected into the cisterna magna enters the peripheral circulation and hence raise the strong possibility that the initial behavioral changes have a peripheral component. Relationships between behavioral changes and levels of brain norepinephrine several hours following injection are discussed.

Submitted on December 7, 1964




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