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Psychosomatic Medicine 28:64-69 (1966)
© 1966 American Psychosomatic Society

Elevated Activation Level as a Primary Characteristic of the Restraint Stress-Ulcer-Susceptible Rat

JACOB O. SINES PH.D.1

1 University of Missouri School of Medicine, Columbia, Mo.

Restraint is more effective in producing gastric ulceration in rats if it is imposed at the peak of their activity cycle or if it is used with characteristically more active rats. That finding plus several additional behavioral characteristics of stress-ulcer-susceptible rats suggest that animals susceptible to stress-ulcers during restraint manifest an elevated level of activation. Hypotheses derived from such an assumption are supported in the behavioral study reported.

Submitted on April 12, 1965




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S. Ackerman, M. Hofer, and H Weiner
Early maternal separation increases gastric ulcer risk in rats by producing a latent thermoregulatory disturbance
Science, July 28, 1978; 201(4353): 373 - 376.
[Abstract] [PDF]


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Copyright © 1966 by the American Psychosomatic Society