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Psychosomatic Medicine 28:443-449 (1966)
© 1966 American Psychosomatic Society

A New Metabolite from Alcohol

W. W. WESTERFELD PH.D.1 and ROBERT J. BLOOM B.S.1

1 Biochemistry Department, State University of New York Upstate Medical Center, Syracuse, N.Y.

Incubation of ethanol-1-C14 with rat liver or kidney homogenate in vitro yielded a heretofore unrecognized metabolite--4-keto, 5-hydroxy-hexanoic acid--with the C14 label in No. 5 carbon of the ketol-caproic acid. This product appeared to be formed by a condensation of acetaldehyde with a-ketoglutarate, and could be formed from these substrates by homogenates of all rat tissues. Its significance in alcohol metabolism has yet to be determined.






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Copyright © 1966 by the American Psychosomatic Society