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Psychosomatic Medicine 28:514-520 (1966)
© 1966 American Psychosomatic Society

Effects of Tetraethylthiuramdisulfide (Antabuse) on the Metabolism and Consumption of Ethanol in Mice

KURT SCHLESINGER PH.D.1, RYOKO KAKIHANA PH.D.1, and EDWARD L. BENNETT PH.D.1

1 Department of Psychology and Psychiatry, University of North Carolina, Chapel Hill, N. C; the Department of Psychology, University of California, Berkeley, Calif.; and the Lawrence Radiation Laboratory, University of California, Berkeley, Calif.

Acetaldehyde accumulation following ethanol administration and the effects of Antabuse on ethanol metabolism were studied in C57BL/CrgI and DBA/2Crgl mice. In alcohol preference tests, C57BL/Crgl mice consistently prefer alcohol to water, whereas DBA/2CrgI mice avoid alcohol. C57BL/Crgl mice were found to accumulate significantly less acetaldehyde than DBA/2Crgl mice following ethanol administration. Antabuse was found to increase acetaldehyde accumulation in both strains, but the effect was significantly greater in C57BL/Crgl than in DBA/2Crgl mice. Antabuse inhibited ethanol-l-1JC metabolism in mice of both strains, but again this effect was significantly greater in C57BL/Crgl than in DBA/2Crgl mice. The effects of Antabuse on voluntary ethanol consumption in C57BL/Crgl, RHI/Crgl, and C3H/Crgl mice was studied: Antabuse treatment decreased alcohol consumption in animals of all three strains.




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E. Garver, A. D. Ross, G.-C. Tu, Q.-N. Cao, F. Zhou, and Y. Israel
PARADIGM TO TEST A DRUG-INDUCED AVERSION TO ETHANOL
Alcohol Alcohol., September 1, 2000; 35(5): 435 - 438.
[Abstract] [Full Text] [PDF]


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