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Psychosomatic Medicine 28:521-528 (1966)
© 1966 American Psychosomatic Society

Metabolism of Rats as Related to Voluntary Alcohol Consumption

OLOF A. FORSANDER PH.D.1

1 Research Laboratories of the State Alcohol Monopoly (Alko), Helsinki, Finland

On basis of experiments done with thiamine-deficient rats it was assumed that a correlation might exist between the preference for alcohol in the self-selection situation and the metabolic tolerance for fat. This hypothesis was tested by giving a fat-load to rats whose voluntary alcohol consumption had been determined and examining how much this fat load disturbed their metabolism. It was found that a good correlation existed between the preference of the animals for alcohol and their metabolic tolerance for fat. Rats that preferred alcohol usually tolerated the fat well, whereas animals preferring the water always were severely disturbed by the fat. In other types of experiments it was shown directly that alcohol produced a shift in the redox level of the liver of those animals preferring water, whereas rats preferring alcohol usually were undisturbed by it.






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Copyright © 1966 by the American Psychosomatic Society