Psychosomatic Medicine 29:345-353 (1967)
© 1967 American Psychosomatic Society

Behavioral and Physiological Rhythms and the Development of Gastric Erosions in the Rat

¹ Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.

Rats immobilized at the peak as compared to the trough in the 24-hr. activity cycle are more susceptible to gastric erosions. In a series of experiments designed to delineate some of the factors which may have contributed to this phenomenon, it was found that the 24-hr. rhythm in plasma corticosterone levels is not correlated with activity and is not related to the development of erosions under 6-hr. immobilization; plasma pepsinogen levels show a 24-hr. rhythm which is synchronized with activity, but the magnitude of the daily fluctuations are not sufficient to account for the altered erosion susceptibility; and the increased susceptibility shown by animals immobilized during a period of maximum activity obtains even when one eliminates animals protected by the presence of food in the stomach.

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