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Psychosomatic Medicine 29:634-642 (1967)
© 1967 American Psychosomatic Society

Chlorpromazine in Women with Chronic Schizophrenia: The Effect on Cholesterol Levels and Cholesterol-Behavior Relationships

M. L. CLARK M.D.1, T. S. RAY PH.D.1, A. PAREDES M.D.1, R. E. RAGLAND M.S.1, J. P. COSTILOE M.S.1, C. W. SMITH M.D.1, and S. WOLF M.D.1

1 Departments of Medicine and Psychiatry and the Biostatistical Unit and Medical Research Computer Center, Department of Preventive Medicine and Public Health, University of Oklahoma Medical Center, Oklahoma City, and Central State Griffin Memorial Hospital, Norman, Okla.

In 2 carefully controlled studies with the same women with chronic schizophrenia, chlorpromazine was shown to raise serum cholesterol levels consistently and significantly. It was also a consistent finding that prior to chlorpromazine therapy cholesterol levels appeared to be related inversely to measures of withdrawal, seclusiveness, and gross psychopathology. After chlorpromazine therapy the cholesterol-behavior relationships were no longer apparent.

Submitted on November 3, 1966




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