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Psychosomatic Medicine 30:390-394 (1968)
© 1968 American Psychosomatic Society

Heritability of Stress-Ulcer Susceptibility in Rats

JACOB O. SINES PH.D.1 and DAVID G. MCDONALD PH.D.1

1 Department of Psychiatry, University of Missouri School of Medicine, Columbia, Mo.

This study was designed to provide estimates of the degree to which stress-ulcer susceptibility in the rat is genetically determined; whether that characteristic is a dominant, intermediate, or recessive trait; and how many genic units may be necessary to account for the observed trait variability. Parental populations of Sprague-Dawley rats and animals of the sixth generation of a stress-ulcer-susceptible (SUS) strain were used to produce F1, F2, and B1, and B2 backcross generations. Analyses of the data on the severity of stress-ulcers that developed during 12 hr. of restraint indicated that: (1) over half the variability in stressulcer susceptibility is genetically determined, and (2) susceptibility is incompletely dominant over resistance to stress-ulceration.

Submitted on December 14, 1967






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Copyright © 1968 by the American Psychosomatic Society