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Psychosomatic Medicine 30:710-720 (1968)
© 1968 American Psychosomatic Society

Urinary Androsterone, Etiocholanolone, and Dehydroepiandrosterone Responses to 72-Hr. Avoidance Sessions in the Monkey

JOHN W. MASON M.D.1, WILEY W. TOLSON PH.D.1, JAMES A. ROBINSON B.S.1, JOSEPH V. BRADY PH.D.1, GERALD A. TOLLIVER M.A.1, and THELMA A. JOHNSON B.S.1

1 Departments of Neuroendocrinology and Experimental Psychology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

Urinary androsterone, etiocholanolone, and dehydroepiandrosterone levels show substantial responses in association with 72-hr. avoidance sessions in the monkey. In most instances a biphasic response is observed which is characterized by a decline in levels during avoidance followed by a rebound elevation during the recovery period. The duration of the two response phases, the primary depression and the secondary elevation, may vary from one experiment to the next, but the general configuration of the response curve remains the same.

The methodological limitations of the present study as well as the need to include androgen measurements in future psychoendocrine studies are discussed.




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