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Psychosomatic Medicine 30:721-732 (1968)
© 1968 American Psychosomatic Society

Urinary Testosterone Response to 72-Hr. Avoidance Sessions in the Monkey

JOHN W. MASON M.D.1, CLYDE C. KENION B.S.1, DAVID R. COLLINS B.S.1, EDWARD H. MOUGEY M.S.1, JOHN A. JONES PH.D.1, GOLDEN C. DRIVER 1, JOSEPH V. BRADY PH.D.1, and BERNARD BEER M.S.1

1 Departments of Neuroendocrinology and Experimental Psychology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

Urinary testosterone levels show a biphasic response in association with 72hr. avoidance sessions in the monkey, characterized by an initial decline during avoidance followed by a rebound elevation during the recovery period. The duration of the two response phases, the primary lowering and the secondary elevation, may vary from one experiment to the next, but the general configuration of the response curve remains the same. Similar testosterone response curves were obtained both with a double-isotope derivative and a gas chromatographic method, although the latter method gave considerably lower absolute values. Preliminary data indicate that urinary epitestosterone levels also change in relation to avoidance in a pattern similar to the testosterone response.

While the mean testosterone curve closely resembles that previously described for urinary androsterone, etiocholanolone, and dehydroepiandrosterone levels, some instances were noted in the present experiments in which there was at least transitory dissociation between the urinary excretion of testosterone and its metabolites. Future study will be required to determine whether this dissociation may possibly be related to eovariation in urinary volume responses, to relatively greater adrenal contribution to androgen metabolite excretion in some experiments, or to other factors.

Preliminary experience with gas chromatographic analysis of other individual 17-ketosteroid compounds indicates that the 11-oxy-17-ketosteroids (C19O3-17-ketosteroids) may show a different response pattern than do androsterone and other C19O2-17-ketosteroid compounds. The pertinence of this observation to the continued use of total urinary 17-ketosteroid determination is discussed, and the need for further psychoendocrine studies of androgen levels with the use of increasingly refined endocrinological methods is emphasized.




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