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Psychosomatic Medicine 30:846-852 (1968)
© 1968 American Psychosomatic Society

Effect of Vagal Stimulation on the Mechanical Properties of the Lungs in Guinea Pigs

W. CHIA-MO WAN M.S.1 and MARVIN STEIN M.D.2

1 Department of Psychiatry, College of Medicine, State University of New York, Downstate Medical Center, Brooklyn, N. Y.; Present address: Michigan State University, East Lansing, Mich.
2 Department of Psychiatry, College of Medicine, State University of New York, Downstate Medical Center, Brooklyn, N. Y.

Vagal stimulation in the intact, unanesthetized guinea pig increased pulmonary resistance and decreased compliance. These findings indicate that stimulation of the vagus in the guinea pig produces bronchoconstriction. The changes in the mechanical properties of the lungs were the same as those previously found in guinea pigs exposed to an aerosol of histamine or in sensitized animals exposed to an aerosolized solution of antigen. These results support the theory that CNS processes may play a role in the development and course of some cases of asthma independent of allergic mechanisms.

Submitted on May 23, 1968






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Copyright © 1968 by the American Psychosomatic Society