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Psychosomatic Medicine 31:45-56 (1969)
© 1969 American Psychosomatic Society

Influence of Pregnancy Upon Gastric Ulcers Induced by Restraint

IRENE G. LUTHER M.D.1, GORDON T. HEISTAD PH.D.1, and SHELDON B. SPARBER PH.D.1

1 Departments of Psychiatry and Neurology, Psychiatry Research Unit, and the Department of Pharmacology, University of Minnesota Medical School

Gastric ulcers were induced in pregnant rats using a modification of Senay and Levine's74 technique of restraint in a cold environment. Under these experimental conditions, pregnancy did not generate ulcer protection and, in fact, increased ulcer incidence was found at the end (twentieth day) of pregnancy. These results are at variance with other reports that pregnancy offered protection against chemically induced gastric ulceration, but seem to confirm clinical observations that an exacerbation of ulcer symptomatology occurs toward the end of pregnancy.

Submitted on August 9, 1968






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Copyright © 1969 by the American Psychosomatic Society