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Psychosomatic Medicine 32:509-514 (1970)
© 1970 American Psychosomatic Society

The Interaction of Psychologic Stimuli and Pharmacologic Agents on Airway Reactivity in Asthmatic Subjects

THOMAS J. LUPARELLO MD1, NANCY LEIST BS1, CARY H. LOURIE MD1, and PAULINE SWEET MD1

1 Department of Psychiatry, State University of New York, Downstate Medical Center Brooklyn, NY

Address for reprint requests: T. Luparello, MD, Department of Psychiatry, State University of New York, Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203

Two bronchoactive substances, isoproterenol and carbachol were presented by inhalation to 20 asthmatic subjects in a double blind study. Each drug was given under two conditions: in one case, the subject was told the drug was a bronchodilator; in the other, he was told it was a bronchoconstrictor. The bronchodilator effect of isoproterenol was greater when the subject was told it was a bronchodilator than when told it was a bronchoconstrictor. Similarly, the bronchoconstricting effect of carbachol was greater when the subject was told it was a bronchoconstrictor than when told it was a bronchodilator.

Submitted on February 5, 1970
Revised on May 7, 1970




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