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Psychosomatic Medicine 33:145-158 (1971)
© 1971 American Psychosomatic Society

Adrenal Function and Alcoholism

I. Serum Cortisol

JACK H. MENDELSON MD1, MOTOI OGATA MD2, and NANCY K. MELLO PhD2

1 National Center for Prevention and Control of Alcoholism, National Institute of Mental Health Chevy Chase, Md.; Professor of Psychiatry, Harvard Medical School; Director, Department of Psychiatry, Boston City Hospital, Boston, Mass 02118.
2 National Center for Prevention and Control of Alcoholism, National Institute of Mental Health Chevy Chase, Md.

Jack H. Mendelson, MD, Department of Psychiatry, Boston City Hospital, 818 Harrison Ave, Boston, Mass 02118.

An increase in serum cortisol levels was found in alcoholic subjects during a period of 11-29 consecutive days of experimentally induced ethanol intoxication. Elevated serum cortisol levels were correlated with a progressive increase in blood alcohol levels, indicating a general dose response relationship. However, blood alcohol levels were Subluenced by factors other than the dose of alcohol ingested. Such factors included intercurrent gastrointestinal disorders and adequacy of dietary intake. Data obtained in this study demonstrate that chronic alcohol ingestion and its concomitant effects are associated with adrenal cortical activation in alcoholics.

Submitted on May 15, 1970
Revised on October 2, 1970






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Copyright © 1971 by the American Psychosomatic Society