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Psychosomatic Medicine 33:159-180 (1971)
© 1971 American Psychosomatic Society

Adrenal Function and Alcoholism

II. Catecholamines

MOTOI OGATA MD1, JACK H. MENDELSON MD2, NANCY K. MELLO PhD1, and EDWARD MAJCHROWICZ PhD1

1 National Center for Prevention and Control of Alcoholism, National Institute of Mental Health Chevy Chase, Md.
2 National Center for Prevention and Control of Alcoholism, National Institute of Mental Health Chevy Chase, Md.; Professor of Psychiatry, Harvard Medical School; Director, Department of Psychiatry, Boston City Hospital, Boston, Mass 02118.

Jack H. Mendelson, MD, Department of Psychiatry, Boston City Hospital, 818 Harrison Ave, Boston, Mass 02118

Urinary excretion of catecholamines and their metabolites were determined in alcoholic subjects during chronic ethanol ingestion and after alcohol withdrawal. A dose response relationship was found between magnitude of blood alcohol levels and increased excretion of epinephrine, metanephrine, norepinephrine and noremetanephrine. Maximal excretion of epinephrine occurred when subjects developed withdrawal signs and symptoms after they had stopped drinking. A significant decrease in excretion of VMA and a concomitant increase in MHPG excretion occurred when subjects were drinking. These data indicate that chronic ethanol ingestion is associated with both stimulation of adrenergic activity and alteration in pathways of catecholamine catabolism.

Submitted on May 15, 1970
Revised on October 2, 1970




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