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Psychosomatic Medicine 33:203-214 (1971)
© 1971 American Psychosomatic Society

Stress, Early Experience and Adjuvant-Induced Arthritis in the Rat

ALFRED A. AMKRAUT PhD1, GEORGE F. SOLOMON MD2, and HELENA C. KRAEMER PhD2

1 Departments of Psychiatry and Medical Microbiology, Stanford University School of Medicine, and the Veterans Administration Hospital, Palo Alto, Calif.
2 Departments of Psychiatry and Medical Microbiology, Stanford University School of Medicine, and the Veterans Administration Hospital Palo Alto, Calif.

Group-housing stress significantly increases the intensity of adjuvant-induced arthritis in the male Fischer rat and can accelerate the time of maximal disease and rate of recovery. Handling in infancy does not alter disease in the adult animal. There are no significant differences in serum proteins, plasma adrenal corticosteroids or fibrinogen between stressed and nonstressed animals.

Submitted on April 23, 1970
Revised on October 28, 1970




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