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Psychosomatic Medicine 33:458-460 (1971)
© 1971 American Psychosomatic Society

Maternal Deprivation and the Response to Ehrlich Carcinoma in BALB/c Mice

RICHARD C. LABARBA PhD1 and JERRY L. WHITE MA1

1 Department of Psychology, University of South Florida Tampa, Fla.

Four of 8 newborn litters of BALB/c mice, each containing 6 pups, were subjected to a maternal deprivation paradigm in which the mothers were removed for 20 hours per day for 18 days. The other 4 litters served as controls. At 60 days of age, all animals were inoculated with 0.2 cu cm of Ehrlich carcinoma. After implantation, all animals were weighed daily until death, with weight increases and survival time recorded for each animal. Maternally deprived mice had significantly longer survival times relative to controls, and showed a differential mortality rate.

Submitted on December 23, 1970
Revised on February 11, 1971




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