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Psychosomatic Medicine 34:505-516 (1972)
© 1972 American Psychosomatic Society

A Longitudinal Study of 21 Subjects with Coronary Heart Disease: Life Changes, Catecholamine Excretion and Related Biochemical Reactions

TÖRES THEORELL 1, EVY LIND 1, JAN FRÖBERG 1, CLAES-GÖRAN KARLSSON 1, and LENNART LEVI 1

1 Departments of Clinical Chemistry and Medicine, Seraphimer Hospital, and the Laboratory for Clinical Stress Research, Karolinska Hospital, Stockholm, Sweden

Address for reprint requests: Dr. Tores Theorell, Serafimerlasarettet, Box 12700, 112 83 Stockholm, Sweden.

Twenty-one male, well-rehabilitated survivors of myocardial infarction participated in repeated observations during a period of 2 to 4 months on the same weekdays and hours of the day. The sum of the self-reported life change units for the week prior to the observation was independently calculated by a psychologist. It was found that several subjects had experienced numerous psychosocial changes during the observation period. Hence, the experiment was suitable for the study of intrasubject variability of physiologic parameters in relation to psychosocial stimuli.

Submitted on July 2, 1971
Revised on March 2, 1972




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