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Psychosomatic Medicine 34:557-559 (1972)
© 1972 American Psychosomatic Society

Brief Communication

The Effects of Maternal Separation, Isolation and Sex on the Response to Ehrlich Carcinoma in BALB/c Mice

RICHARD C. LABARBA PhD1, JOEL M. LAZAR MA1, and JERRY L. WHITE MA1

1 Department of Psychology, University of South Florida, Tampa, Florida 33620

Address for reprint requests: Richard C. LaBarba, PhD, Department of Psychology, University of Southern Florida, Tampa, Florida 33620

BALB/c mice were weaned from their mothers at either 14, 17 or 21 days of age. At 21 days all animals were either isolated or paired with a cagemate of the same sex. At 45 days the mice were inoculated with 0.2 ml of Ehrlich ascites carcinoma. Weight changes and survival time were recorded. Animals housed in pairs survived significantly longer than did those housed individually. A significant sex difference was also found, with males surviving longer than females. There were no differences in mortality rates among the three maternal separation groups.

Submitted on April 20, 1972
Revised on June 30, 1972




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