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Psychosomatic Medicine 35:143-154 (1973)
© 1973 American Psychosomatic Society

Correlations Between Mood, Weight, and Electrolytes During the Menstrual Cycle: A Renin-Angiotensin-Aldosterone Hypothesis of Premenstrual Tension

DAVID S. JANOWSKY 1, STEPHEN C. BERENS 2, and JOHN M. DAVIS 1

1 Departments of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Tennessee Neuropsychiatric Institute, Nashville, Tennessee, and the Laboratory of Clinical Science, National Institutes of Mental Health, Bethesda, Maryland
2 Division of Cardiology, UCLA Department of Medicine, Los Angeles, California

Address for reprint requests: David S. Janowsky, M. D., Dept. of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37203.

Eleven female college age volunteers were studied over a total of 15 menstrual cycles under controlled conditions. Daily weights, urinary potassium/sodium ratios and self evaluations of negative affect were obtained. The different variables changed throughout the menstrual cycle, and were elevated in the luteal-premenstrual and early menstrual phases and decreased at other times. The potassium/sodium ratio and weight changes suggest that activation of the renin-angiotensin-aldosterone system may underlie increases in psychopathology linked to the menstrual cycle, possibly through effects on central neurotransmitters.

Submitted on May 26, 1972
Revised on July 21, 1972




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D. Ruble
Premenstrual symptoms: a reinterpretation
Science, July 15, 1977; 197(4300): 291 - 292.
[Abstract] [PDF]


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Copyright © 1973 by the American Psychosomatic Society