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Psychosomatic Medicine 36:241-247 (1974)
© 1974 American Psychosomatic Society

Corticosterone, Prolactin, and Growth Hormone Responses to Handling and New Environment in the Rat

GREGORY M. BROWN MD, PHD, FRCP(C)1 and JOSEPH B. MARTIN MD, PHD, FRCP(C)1

1 Department of Psychiatry, University of Toronto and the Neuroendocrinology Research Section, Clarke Institute of Psychiatry, Toronto, Canada, and the Department of Neurology, McGill University, and the Division of Neurology, Department of Medicine, Montreal General Hospital, Montreal, Canada

Address for reprint requests: Dr. Gregory M. Brown, Head, Neuroendocrinology Research Section, Clarke Institute of Psychiatry, 250 College Street, Toronto, Ontario M5T 1R8

Temporal characteristics of hormonal responses to handling and novel environment were studied in the rat in order to determine whether the same factors which modify corticosterone responses, i.e., time of day and type of stimulus, also modify prolactin and GH responses. Resting corticosterone showed the expected difference between crest and trough of the diurnal cycle. In contrast, GH and prolactin showed no difference at these times. Prolactin elevation occurred in response to the same stimuli which produced adrenal activation. Prolactin responses, however, differed from adrenal responses in being more rapid at the trough of the adrenal cycle and slower at the crest. In contrast to prolactin and corticosterone, GH showed a drop (nonsignificant) following stimulation. It is concluded that prolactin and corticosterone both respond to identical stimuli but that the prolactin response shows different characteristics from the adrenal response suggesting that different regulatory mechanisms are involved.

Submitted on September 7, 1973
Revised on December 10, 1973




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