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Psychosomatic Medicine 36:258-268 (1974)
© 1974 American Psychosomatic Society

The Three Investigators Study. Serum Uric Acid, Cholesterol, and Cortisol Variability During Stresses of Everyday Life

RICHARD H. RAHE CDR MC, USNR1, ROBERT T. RUBIN MD1, and RANSOM J. ARTHUR CAPT MC, USN1

1 Biochemical Correlates Division, U.S. Navy Medical Neuropsychiatric Research Unit, San Diego, California 92152; Department of Psychiatry, University of California at Los Angeles (Harbor Campus)

Serum uric acid, cholesterol, and cortisol variability were studied, semiweekly, over three to six months' time in three medical investigators as they underwent the stresses of everyday life. These men maintained diaries of their life events, with particular references to moods and feelings engendered by these events. Marked elevations in serum cholesterol was seen in one investigator throughout an unpleasant residential move; repeated peaks in serum cortisol were seen in one investigator during times of anguish and anger over personal disappointments and work changes. Two of the three men showed uric acid elevations into the "gout range" prior to eagerly taking on a physical change. Occasionally, serum uric acid and cortisol values reached magnitudes previously reported as characteristic of men entering underwater demolition training and jumping into the ocean from hovering helicopters.

Submitted on November 19, 1973
Revised on January 21, 1974




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