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Psychosomatic Medicine, Vol 40, Issue 5 432-434, Copyright © 1978 by American Psychosomatic Society

ORIGINAL ARTICLES

Effect of signaled versus unsignaled stress of rat myocardium

DG Miller, ZD Grossman, RL Richardson, BW Wistow and FD Thomas

Foot-shock stress resulted in a threefold increase in myocardial uptake of technetium-99m-methylene diphosphonate (Tc-99m-MDP) in rats compared to unstressed controls. The introduction of a 4-sec signal prior to each shock resulted in a two-thirds reduction in this stress-induced Tc-99m-MDP myocardial uptake, suggesting that most of the stress-induced myocardial damage was psychologically mediated.




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Copyright © 1978 by the American Psychosomatic Society