Psychosomatic Medicine Faster Service from Outside North America
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pavlidis, N.
Right arrow Articles by Chirigos, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pavlidis, N.
Right arrow Articles by Chirigos, M.

Psychosomatic Medicine, Vol 42, Issue 1 47-54, Copyright © 1980 by American Psychosomatic Society

ORIGINAL ARTICLES

Stress-induced impairment of macrophage tumoricidal function

N Pavlidis and M Chirigos

Several studies have shown the effect of stress on immune cells and their functions. The purpose of the present work was to investigate the influence of acute immobilization stress on macrophage nonspecific tumoricidal activity. Peritoneal macrophages were activated by nonspecific immunopotentiators such as interferon or bacterial lipopolysaccharide (LPS) and the killing of MBL-2 leukemic target cells was measured. Macrophages from mice submitted to stress showed decreased responsiveness to interferon or LPS. In addition, the role of corticosteroids as mediators in the phenomenon was also studied. Indeed, we observed that corticosteroids were able to inhibit macrophage cytotoxicity and could at least play some role. This data could contribute to a better understanding of the effect of stress on the host immunosurveillance against tumor development.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by the American Psychosomatic Society