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Psychosomatic Medicine, Vol 43, Issue 1 3-18, Copyright © 1981 by American Psychosomatic Society

ORIGINAL ARTICLES

Depressed mood and other psychiatric manifestations of Cushing's syndrome: relationship to hormone levels

MN Starkman, DE Schteingart and MA Schork

Thirty-five consecutive patients with Cushing's syndrome were studied prospectively prior to treatment. A consistent constellation of psychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decreased libido and insomnia). A statistically significant relationship was found between the overall psychiatric disability rating and cortisol and ACTH level. The relationship of depressed mood and hormone levels was examined. Low ACTH levels were significantly associated with milder rather than pronounced depressed mood. The implications of the similarities in psychiatric manifestations between Cushing's syndrome and the primary affective disorders are discussed.


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