Psychosomatic Medicine Faster Service from Outside North America
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huang, S. W.
Right arrow Articles by Wareheim, L. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huang, S. W.
Right arrow Articles by Wareheim, L. E.

Psychosomatic Medicine, Vol 43, Issue 5 431-437, Copyright © 1981 by American Psychosomatic Society

ORIGINAL ARTICLES

Effect of stressful stimulation on the incidence of streptozotocin-induced diabetes in mice

SW Huang, SM Plaut, G Taylor and LE Wareheim

In three experiments, groups of 8-18, 45-day-old male CD-1 mice were injected with a single dose of streptozotocin (STZ) and were followed for 12-31 weeks. Experimental groups were given periodic. light-shock stimulation beginning at various times after streptozotocin injection. Blood samples were taken biweekly from all mice. Blood glucose levels were attenuated over a 22 week period in mice that were stimulated during the first 72 hours after STZ injection. Incidence of insulin-dependent diabetes (blood glucose levels over 150 mg%) was also significantly reduced in stimulated mice. Progressively increasing correlations between sampling order and blood glucose levels, which were significant over the last 12 weeks of one experiment, indicated that blood glucose levels of caged, diabetic mice responded markedly to laboratory procedures.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by the American Psychosomatic Society