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Psychosomatic Medicine, Vol 44, Issue 2 215-223, Copyright © 1982 by American Psychosomatic Society

ORIGINAL ARTICLES

Absence of naloxone sensitivity in obese humans

CP O'Brien, AJ Stunkard and JW Ternes

Studies in rodents suggest the possibility of an association between elevated endogenous opiate activity and overeating and obesity. One measure of elevated opiate activity is sensitivity to the opiate antagonist naloxone. Seven massively obese human subjects showed no subjective or physiological sensitivity to large intravenous doses of naloxone. This finding fails to support a relationship between elevated endorphin activity and human obesity.




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Copyright © 1982 by the American Psychosomatic Society