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Psychosomatic Medicine, Vol 45, Issue 1 65-70, Copyright © 1983 by American Psychosomatic Society

ORIGINAL ARTICLES

Psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans

GR Smith Jr and SM McDaniel

Recent research with animals has indicated a central nervous system effect on the immune system. This report describes findings of a possible psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans. Seven tuberculin positive subjects evidenced a decreased response to tuberculin (as measured by erythema and induration) when a paradigm similar to behavioral conditioning was followed where the subjects expected their reactions to be negative.


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Copyright © 1983 by the American Psychosomatic Society