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Psychosomatic Medicine, Vol 46, Issue 4 315-331, Copyright © 1984 by American Psychosomatic Society

ORIGINAL ARTICLES

Behavioral control of intractable idiopathic seizures: I. Self-regulation of end-tidal carbon dioxide

R Fried, SR Rubin, RM Carlton and MC Fox

Eleven women and seven men with moderate to severe chronic hyperventilation and idiopathic seizures refractory to therapeutic serum levels of anticonvulsant medication were given diaphragmatic respiration training with percent end-tidal CO2 biofeedback. The training had a rapid correcting effect on their respiration, making it comparable to that of 18 asymptomatic control subjects. Ten of the seizure-group subjects were in the study at least 7 months and following treatment, 8 showed EEG power spectrum "normalization", restoration of cardio-respiratory synchrony (RSA), and their seizure frequency and severity were significantly reduced.


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Y. Nagai, H. D. Critchley, J. C. Rothwell, J. S. Duncan, and M. R. Trimble
Changes in Cortical Potential Associated With Modulation of Peripheral Sympathetic Activity in Patients With Epilepsy
Psychosom Med, January 1, 2009; 71(1): 84 - 92.
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Copyright © 1984 by the American Psychosomatic Society