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Psychosomatic Medicine, Vol 47, Issue 2 132-138, Copyright © 1985 by American Psychosomatic Society

ORIGINAL ARTICLES

Naloxone reduces food intake in humans

MR Cohen, RM Cohen, D Pickar and DL Murphy

Hypotheses generated from animal studies that the endogenous opioid system is an important modulator of food intake suggest that blockade of the system in humans should affect eating behavior. To assess this hypothesis, seven normal volunteers were given 2 mg/kg naloxone or placebo on separate days in a double-blind, random but balanced cross-over experimental design. Compared to placebo, naloxone was found to reduce significantly total food intake from preselected prepared trays served 2.75 and 7.75 hours after drug administration (p less than 0.02). The reduction was considerable (28%), and although the magnitude varied greatly among individuals, reduction occurred in each. This reduced food intake was not accompanied by a demonstrable alteration of the volunteers' perceptions of their hunger. Further cautious experimental investigation of naloxone's effects during long-term administration and in patients with eating disorders is warranted in light of its apparent effect of reducing food intake in humans while not decreasing their satiety.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. A. Statnick, F. C. Tinsley, B. J. Eastwood, T. M. Suter, C. H. Mitch, and M. L. Heiman
Peptides that Regulate Food Intake: Antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1399 - R1408.
[Abstract] [Full Text] [PDF]


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