Psychosomatic Medicine Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sherwin, B. B.
Right arrow Articles by Brender, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sherwin, B. B.
Right arrow Articles by Brender, W.

Psychosomatic Medicine, Vol 47, Issue 4 339-351, Copyright © 1985 by American Psychosomatic Society

ORIGINAL ARTICLES

Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause

BB Sherwin, MM Gelfand and W Brender

Various parameters of sexual functioning were assessed in a prospective, crossover investigation of 53 surgically menopausal women. Patients randomly received either an estrogen-androgen combined preparation, an estrogen-alone drug, an androgen-alone drug, or a placebo. Also included were a group of women who had undergone hysterectomy and whose ovaries had been left intact. Two treatment phases, each of 3 months' duration, were separated by an intervening placebo month. Additionally, plasma levels of total estrogens and testosterone were assayed four times during the study concurrent with monitoring of sexual behaviors. It was clear that exogenous androgen enhanced the intensity of sexual desire and arousal and the frequency of sexual fantasies in hysterectomized and oophorectomized women. However, there was no evidence that testosterone affected physiologic response or interpersonal aspects of sexual behavior. These findings suggest that the major impact of androgen in women is on sexual motivation and not on sexual activity per se.


This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
E. Elaut, G. De Cuypere, P. De Sutter, L. Gijs, M. Van Trotsenburg, G. Heylens, J.-M. Kaufman, R. Rubens, and G. T'Sjoen
Hypoactive sexual desire in transsexual women: prevalence and association with testosterone levels
Eur. J. Endocrinol., March 1, 2008; 158(3): 393 - 399.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
W. Arlt
Androgen therapy in women
Eur. J. Endocrinol., January 1, 2006; 154(1): 1 - 11.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. B. Singh, M. L. Lee, I. Sinha-Hikim, M. Kushnir, W. Meikle, A. Rockwood, S. Afework, and S. Bhasin
Pharmacokinetics of a Testosterone Gel in Healthy Postmenopausal Women
J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 136 - 144.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J Bancroft
The endocrinology of sexual arousal
J. Endocrinol., September 1, 2005; 186(3): 411 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Simon, G. Braunstein, L. Nachtigall, W. Utian, M. Katz, S. Miller, A. Waldbaum, C. Bouchard, C. Derzko, A. Buch, et al.
Testosterone Patch Increases Sexual Activity and Desire in Surgically Menopausal Women with Hypoactive Sexual Desire Disorder
J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5226 - 5233.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Bhasin
Female Androgen Deficiency Syndrome--An Unproven Hypothesis
J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4970 - 4972.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
G. D. Braunstein, D. A. Sundwall, M. Katz, J. L. Shifren, J. E. Buster, J. A. Simon, G. Bachman, O. A. Aguirre, J. D. Lucas, C. Rodenberg, et al.
Safety and Efficacy of a Testosterone Patch for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women: A Randomized, Placebo-Controlled Trial
Arch Intern Med, July 25, 2005; 165(14): 1582 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
J. E. Buster, S. A. Kingsberg, O. Aguirre, C. Brown, J. G. Breaux, A. Buch, C. A. Rodenberg, K. Wekselman, and P. Casson
Testosterone Patch for Low Sexual Desire in Surgically Menopausal Women: A Randomized Trial
Obstet. Gynecol., May 1, 2005; 105(5): 944 - 952.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
V. Lewis
Female sexual dysfunction
BMJ, April 16, 2005; 330(7496): E345 - E346.
[Full Text] [PDF]

Home page
 J Clin PharmacolHome page
S. Davison, J. Thipphawong, J. Blanchard, K. Liu, R. Morishige, I. Gonda, J. Okikawa, J. Adams, A. Evans, B. Otulana, et al.
Pharmacokinetics and Acute Safety of Inhaled Testosterone in Postmenopausal Women
J. Clin. Pharmacol., February 1, 2005; 45(2): 177 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
Sexual Dysfunction
Obstet. Gynecol., October 1, 2004; 104(4_suppl): 85S - 91S.
[Full Text] [PDF]

Home page
 Endocr. Rev.Home page
W. Somboonporn and S. R. Davis
Testosterone Effects on the Breast: Implications for Testosterone Therapy for Women
Endocr. Rev., June 1, 2004; 25(3): 374 - 388.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
H. B. Miller and J. S. Hunt
Female Sexual Dysfunction: Review of the Disorder and Evidence for Available Treatment Alternatives
Journal of Pharmacy Practice, June 1, 2003; 16(3): 200 - 208.
[Abstract] [PDF]

Home page
 The Annals of PharmacotherapyHome page
K. R Ragucci and N. S Culhane
Treatment of Female Sexual Dysfunction
Ann. Pharmacother., April 1, 2003; 37(4): 546 - 555.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
F. Modugno, R. B. Ness, S. Ewing, and J. A. Cauley
Effect of Raloxifene on Sexual Function in Older Postmenopausal Women With Osteoporosis
Obstet. Gynecol., February 1, 2003; 101(2): 353 - 361.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
B. Z. Leder, K. M. LeBlanc, C. Longcope, H. Lee, D. H. Catlin, and J. S. Finkelstein
Effects of Oral Androstenedione Administration on Serum Testosterone and Estradiol Levels in Postmenopausal Women
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5449 - 5454.
[Abstract] [Full Text] [PDF]

Home page
 Pers Soc Psychol RevHome page
R. F. Baumeister, K. R. Catanese, and K. D. Vohs
Is There a Gender Difference in Strength of Sex Drive? Theoretical Views, Conceptual Distinctions, and a Review of Relevant Evidence
Personality and Social Psychology Review, August 1, 2001; 5(3): 242 - 273.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. K. Miller
Androgen Deficiency in Women
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2395 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. Rymer and E. P Morris
Extracts from "Clinical Evidence": Menopausal symptoms
BMJ, December 16, 2000; 321(7275): 1516 - 1519.
[Abstract] [Full Text]

Home page
 Arch Gen PsychiatryHome page
C. M. Meston and P. F. Frohlich
The Neurobiology of Sexual Function
Arch Gen Psychiatry, November 1, 2000; 57(11): 1012 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. L. Shifren, G. D. Braunstein, J. A. Simon, P. R. Casson, J. E. Buster, G. P. Redmond, R. E. Burki, E. S. Ginsburg, R. C. Rosen, S. R. Leiblum, et al.
Transdermal Testosterone Treatment in Women with Impaired Sexual Function after Oophorectomy
N. Engl. J. Med., September 7, 2000; 343(10): 682 - 688.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. S. Guzick and K. Hoeger
Sex, Hormones, and Hysterectomies
N. Engl. J. Med., September 7, 2000; 343(10): 730 - 731.
[Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. A. Laughlin, E. Barrett-Connor, D. Kritz-Silverstein, and D. von Mühlen
Hysterectomy, Oophorectomy, and Endogenous Sex Hormone Levels in Older Women: The Rancho Bernardo Study
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 645 - 651.
[Abstract] [Full Text]

Home page
 Arch Gen PsychiatryHome page
A. Tuiten, J. Van Honk, H. Koppeschaar, C. Bernaards, J. Thijssen, and R. Verbaten
Time Course of Effects of Testosterone Administration on Sexual Arousal in Women
Arch Gen Psychiatry, February 1, 2000; 57(2): 149 - 153.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
C. N. Epperson, K. L. Wisner, and B. Yamamoto
Gonadal Steroids in the Treatment of Mood Disorders
Psychosom Med, September 1, 1999; 61(5): 676 - 697.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Davis
Androgen Replacement in Women: A Commentary
J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1886 - 1891.
[Abstract] [Full Text]

Home page
 BMJHome page
J Herbert
Oxytocin and sexual behaviour
BMJ, October 8, 1994; 309(6959): 891 - 892.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American Psychosomatic Society