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Psychosomatic Medicine 5:143-147 (1943)
© 1943 American Psychosomatic Society
1 United States Public Health Service, United States Public Health Service Hospital, Lexington, Kentucky; National Institute of Health, Bethesda, Maryland
The assumption of a cortical excitatory state satisfactorily explains the action of repeated doses of morphine. Morphine acts to depress the cortical excitation but this is not necessarily accompanied by a change in the level of alertness. Tolerance to the cortical depressing effect appears to be developed at quite different rates in different individuals.
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