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Psychosomatic Medicine, Vol 52, Issue 6 621-623, Copyright © 1990 by American Psychosomatic Society
ORIGINAL ARTICLES |
PJ Mills, JE Dimsdale, MG Ziegler, CC Berry and RD Bain
Department of Psychiatry, University of California, San Diego, La Jolla 92093.
We examined the ability of baseline measures of receptors (lymphocyte beta-adrenergic) and nonreceptors (plasma catecholamines, heart rate, and blood pressure) to predict cardiovascular responses to a mental arithmetic task. Twenty-five male volunteers served as subjects. Nonreceptor measures predicted the heart rate response to stress poorly (p = 0.67). However, beta receptor density and sensitivity explained 48.4% of the variance in heart rate response (p = 0.007). When both receptor and nonreceptor measures were used together, they predicted 76.6% of the variance (p = 0.005), which was more than was explained by either receptor or nonreceptor baseline measurements alone (p = 0.001). Receptor measures may thus greatly improve the prediction of reactivity.
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