Psychosomatic Medicine Faster Service from Outside North America
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Facchinetti, F.
Right arrow Articles by Genazzani, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Facchinetti, F.
Right arrow Articles by Genazzani, A. R.

Psychosomatic Medicine, Vol 54, Issue 3 288-296, Copyright © 1992 by American Psychosomatic Society

ORIGINAL ARTICLES

Lactate infusion induces panic attacks in patients with premenstrual syndrome

F Facchinetti, G Romano, M Fava and AR Genazzani
Department of Obstetrics and Gynecology, University of Modena, School of Medicine, Italy.

A sodium lactate test was performed during the premenstrual phase in 35 women suffering from prospectively confirmed premenstrual syndrome (PMS) and in 16 controls in order to assess whether these patients were sensitive to this test and whether this sensitivity was accounted for primarily by the presence of concomitant panic disorder. Patients with PMS also underwent the Structured Clinical Interview for the DSM-III-R (SCID) to determine the presence of co-morbid anxiety and/or mood disorders. Only 31% of the PMS patients were free from a depressive/anxiety disorder, while nine patients met criteria for panic disorder, and the remaining 15 subjects were diagnosed as having anxiety and/or mood disorders. Lactate infusion induced panic attacks in 22 subjects (62.9%) and two controls (12.5%). Panickers were equally distributed among PMS patients with or without a concurrent anxiety/mood disorder. Although cardiovascular responses to lactate were similar among PMS patients regardless of the presence of concomitant anxiety/mood disorders, both plasma cortisol levels and panic and mood scores were higher during the test in those patients with concomitant panic disorder. These results suggest that PMS patients display an increased sensitivity to lactate, which is not primarily accounted for by the presence of co-morbid panic disorder.


This article has been cited by other articles:


Home page
 J PsychopharmacolHome page
T. Sajdyk, P. Johnson, S. Fitz, and A. Shekhar
Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior
J Psychopharmacol, August 1, 2008; 22(6): 633 - 641.
[Abstract] [PDF]

Home page
 JAMAHome page
J. M. Gorman
A 28-Year-Old Woman With Panic Disorder
JAMA, July 25, 2001; 286(4): 450 - 457.
[Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. M. Kent, L. A. Papp, J. M. Martinez, S. T. Browne, J. D. Coplan, D. F. Klein, and J. M. Gorman
Specificity of Panic Response to CO2 Inhalation in Panic Disorder: A Comparison With Major Depression and Premenstrual Dysphoric Disorder
Am J Psychiatry, January 1, 2001; 158(1): 58 - 67.
[Abstract] [Full Text]

Home page
 NeuroscientistHome page
T.A. Lovick
Panic Disorder-A Malfunction of Multiple Transmitter Control Systems within the Midbrain Periaqueductal Gray Matter?
Neuroscientist, February 1, 2000; 6(1): 48 - 59.
[Abstract] [PDF]

Home page
 Nephrol Dial TransplantHome page
D. Zimmerman, P. Cotman, R. Ting, S. Karanicolas, and S. W. Tobe
Continuous veno–venous haemodialysis with a novel bicarbonate dialysis solution: prospective cross-over comparison with a lactate buffered solution
Nephrol. Dial. Transplant., October 1, 1999; 14(10): 2387 - 2391.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the American Psychosomatic Society