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Psychosomatic Medicine, Vol 56, Issue 1 70-76, Copyright © 1994 by American Psychosomatic Society

ORIGINAL ARTICLES

Patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a psychological challenge

PJ Mills, JE Dimsdale, RA Nelesen, J Jasiewicz, MG Ziegler and B Kennedy
Department of Psychiatry, University of California, San Diego 92093.

Numerous physiological and biochemical factors contribute to the dynamic regulation of the cardiovascular system. This study used a cluster analytic statistical technique to discern patterns of adrenergic receptors and adrenergic agonists underlying cardiovascular responses to a laboratory challenge. Fifty hypertensive and normotensive black and white individuals had their beta- and alpha-adrenergic receptor sensitivity determined through agonist infusions. Norepinephrine, epinephrine, blood pressure, and heart rate responses to a standardized mental arithmetic task were also obtained. The cluster analysis identified four subgroups of individuals having distinct patterns of receptor and neurohormonal regulation of end-organ responses. In general, the data indicated that end-organ cardiovascular responses are, in part determined by the sensitivity of adrenergic receptors and the accompanying catecholamine responses. The findings also suggest that for some individuals nonadrenergic factors play a more dominant role than adrenergic mechanisms in determining cardiovascular pressor responses.


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