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Psychosomatic Medicine, Vol 56, Issue 4 290-295, Copyright © 1994 by American Psychosomatic Society

ORIGINAL ARTICLES

Effects of chronic stress on beta-adrenergic receptors in the homeless

JE Dimsdale, P Mills, T Patterson, M Ziegler and E Dillon
University of California, San Diego 92093-0804.

This study examined the role of chronic life stress (homelessness), coping style, and hypertension on beta-adrenergic receptors in a sample of homeless men. Sixteen healthy normotensive subjects and nine untreated hypertensive subjects were studied. Life stress was measured with the Brown and Harris categorization; coping style was measured with the Ways of Coping Scale. Lymphocyte beta-adrenergic receptors were characterized in terms of receptor density (Bmax). Individuals with high life stress had lower Bmax (p < .005). In multiple regression analyses, 50% of the variance in Bmax was accounted for by life stress and coping style (p = .01). Receptor measures may be useful for characterizing the physiological response to continuing life adversity.


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