| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Psychosomatic Medicine, Vol 57, Issue 2 97-104, Copyright © 1995 by American Psychosomatic Society
ORIGINAL ARTICLES |
D Uthgenannt, D Schoolmann, R Pietrowsky, HL Fehm and J Born
Department of Internal Medicine, University of Lubeck, Germany.
The restorative functions of sleep may affect immunologic functioning. The present study examined the effects of sleep on stimulated cytokine release in 13 healthy men. The subjects spent 2 experimental nights in the sleep laboratory. In one condition, lights were turned off at 11:00 PM to enable sleep for 3.5 hours. Thereafter, they stayed awake till 7:00 AM. In the other condition, conversely, subjects stayed awake between 11:00 PM and 3:00 AM. Then, lights were turned off for a 3.5-hour phase of sleep. Blood was sampled every 30 minutes between 11:00 PM and 7:00 AM. Sleep was monitored by polysomnographic recordings. Release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) was determined after stimulation of mononuclear cells with lipopolysaccharide from Escherichia coli. The release of IL-2 was stimulated with phytohemagglutinin. Compared with wakefulness, after 3 hours of sleep, production of TNF-alpha and IL-1 beta was substantially diminished (p < .01). Production of IL-2 was enhanced during sleep (p < .05), with this effect being limited to the second nocturnal sleep phase after 3:00 AM. Sleep-dependent changes in stimulated cytokine release were independent of changes in plasma cortisol concentrations. These results indicate a specific reducing effect of sleep (vs. wakefulness) on cytokine production by monocytes (TNF-alpha and IL-1 beta). The rather slow development of the effects calls for further studies to establish the exact time course of the influence of sleep on cytokine production.
This article has been cited by other articles:
 |
|
 |
|
  J. L. Steel, D. A. Geller, T. C. Gamblin, M. C. Olek, and B. I. Carr Depression, Immunity, and Survival in Patients With Hepatobiliary Carcinoma J. Clin. Oncol., June 10, 2007; 25(17): 2397 - 2405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Arjona and D. K. Sarkar Circadian Oscillations of Clock Genes, Cytolytic Factors, and Cytokines in Rat NK Cells J. Immunol., June 15, 2005; 174(12): 7618 - 7624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tada, S. Satoh, M. Iinuma, N. Shimoda, M. Murakami, Y. Hayase, T. Kato, and T. Suzuki Chronopharmacokinetics of Tacrolimus in Kidney Transplant Recipients: Occurrence of Acute Rejection J. Clin. Pharmacol., August 1, 2003; 43(8): 859 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Redwine, J. Dang, M. Hall, and M. Irwin Disordered Sleep, Nocturnal Cytokines, and Immunity in Alcoholics Psychosom Med, January 1, 2003; 65(1): 75 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Kiecolt-Glaser, L. McGuire, T. F. Robles, and R. Glaser Psychoneuroimmunology and Psychosomatic Medicine: Back to the Future Psychosom Med, January 1, 2002; 64(1): 15 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kubota, R. A. Brown, J. Fang, and J. M. Krueger Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R1004 - R1012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kubota, J. Fang, Z. Guan, R. A. Brown, and J. M. Krueger Vagotomy attenuates tumor necrosis factor-{alpha}-induced sleep and EEG {delta}-activity in rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1213 - R1220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Irwin, J. Thompson, C. Miller, J. C. Gillin, and M. Ziegler Effects of Sleep and Sleep Deprivation on Catecholamine And Interleukin-2 Levels in Humans: Clinical Implications J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 1979 - 1985. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. Dickstein, H. Moldofsky, F. A. Lue, and J. B. Hay Intracerebroventricular injection of TNF-alpha promotes sleep and is recovered in cervical lymph Am J Physiol Regulatory Integrative Comp Physiol, April 1, 1999; 276(4): R1018 - R1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kushikata, J. Fang, Y. Wang, and J. M. Krueger Interleukin-4 inhibits spontaneous sleep in rabbits Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1185 - R1191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fang, Y. Wang, and J. M. Krueger Mice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFalpha Treatment J. Neurosci., August 1, 1997; 17(15): 5949 - 5955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Drange and S. Melmed To Sleep, Perchance To Eat J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1311 - 1312. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
