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Psychosomatic Medicine, Vol 57, Issue 3 269-274, Copyright © 1995 by American Psychosomatic Society
ORIGINAL ARTICLES |
JK Kiecolt-Glaser and R Glaser
Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210, USA.
There is evidence linking psychosocially mediated immunological alterations with cancer, infectious illness, and HIV progression. The data reviewed suggest that immune modulation by psychosocial stressors and/or interventions may importantly influence health status. The research literature also suggests that the impact of chronic stressors and psychosocial factors on sympathetic nervous system and endocrine function influences the immune system, thereby providing shared mechanisms that may impact on disease susceptibility and progression across a broad spectrum of disorders. A better understanding of individual vulnerability, such as occurs with aging, may help to pinpoint those at greatest risk.
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